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K Tsuchida, M. Kobayashi:
Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin.
Scientific Reports Vol. 10, 21667 (2020) [pdf]
https://doi.org/10.1038/s41598-020-78884-0K Tsuchida, M. Kobayashi:
Oxidative stress in human facial skin observed by ultraweak photon emission imaging and its correlation with biophysical properties of skin.
Scientific Reports Vol. 10, 9626 (2020) [pdf]
https://doi.org/10.1038/s41598-020-66723-1K Tsuchida, T. Iwasa, M. Kobayashi:
Imaging of ultraweak photon emission for evaluating the oxidative stress of human skin.
J Photochem Photomiol. B Vol. 198, 111562 (2019) [pdf]
https://doi.org/10.1016/j.jphotobiol.2019.111562S. Usui, M. Tada, M. Kobayashi:
Non-invasive visualization of physiological changes of insects during metamorphosis based on biophoton emission imaging.
Scientific Reports Vol. 9, Article number: 8576 (2019) [pdf]
https://doi.org/10.1038/s41598-019-45007-3M. Kobayashi, T. Iwasa, M. Tada:
Polychromatic spectral pattern analysis of ultra-weak photon emissions from a human body.
J. Photochem. Photobol. B: Biology Vol. 159, 186-190 (2016)Y. Yamaguchi, K. Okada, T. Mizuno, T. Ota, H. Yamada, M. Doi, M. Kobayashi, H. Tei, Y. Shigeyoshi, H. Okamura:
Real-time recording of circadian Per1 and Per2 expression in the suprachiasmatic nucleus of freely moving rats.
J Biol Rhythms Vol. 31, No. 1, 108-111 (2016)M. Kobayashi, N. Kikuchi, A. Sato:
Ultrasound-enhanced chemiluminescence tomography in biological tissue.
Ultrasonics Sonochemistry Vol. 31, 1-6 (2016)M. He, E. Van Wijk, R. Berger, M. Wang, K. Strassburg, J. C. Schoeman, R. Vreeken, H. A. Van Wietmarschen, A. Harms, M. Kobayashi, T. Hankemeier. J. V. van der Greef:
Collagen induced arthritis in DBA/1J mice Associates with oxylipin changes in plasma.
Mediators of InflammationVol. 2015, Article ID 543541, 1-11 (2015)M. Kobayashi, N. Kikuchi, A. Sato:
Optical tomography of fluorophores in dense scattering media based on ultrasound-enhanced chemiluminescence.
Appl. Phys. Lett. Vol. 106 021103 (2015)M. Kobayashi:
Highly sensitive imaging for ultra-weak photon emission from living organisms.
J. Photochem. Photobiol. B: Biology Vol. 139, pp. 34-38 (2014)E. van Wijk, M. Kobayashi, R. van Wijk, J. van der Greef:
Imaging of ultra-weak photon emission in a rheumatoid arthritis mouse model.
PLoS ONE Vol. 8, No. 12, e84579 pp. 1-6 (2013) [pdf]Q. D. Trinh, S. Kaneta, M. Kobayashi:
Study on mechanism of ultrasonic fluorescence modulation in light scattering medium based on diffusion approximation with varying refractive index
Optical Review Vol. 19, No. 3, pp. 159-166 (2012)Q. D. Trinh, S. Kaneta, M. Kobayashi:
Development of UltrasonicModulation Probe for Fluorescence Tomography Based on Acousto-Optic Effect
Int. J. Optics Vol. 2011, Artile ID 818302 (2011) [pdf 1.31MB]M. Doi,, A. Ishida, A. Miyake, M. Sato, R. Komatsu, F. Yamazaki, I. Kimura, S. Tsuchiya, H. Kori, K. Seo, Y. Yamaguchi, M. Matsuo, J-M. Fustin, R. Tanaka, Y. Santo, H. Yamada, Y. Takahashi, M. Araki, K. Nakao, S. Aizawa, M. Kobayashi, K. Obrietan, G. Tsujimoto, H. Okamura:
Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus
Nature communications, Vol. 2, article number 327 (2011)M. Kobayashi, D. Kikuchi, H. Okamura:
Imaging of Ultraweak Spontaneous Photon Emission from Human Body Displaying Diurnal Rhythm
PLoS ONE Vol. 4, No. 7, e6256 (2009) [pdf 0.24MB]M. Kobayashi, T. Mizumoto, T. Q. Duc, M. Takeda:
Fluorescence Tomography of Biological Tissue Based on Ultrasound Tagging Technique
Proc. SPIE 6633, pp. 663306-1-5 (2007)M. Kobayashi, K. Sasaki, M. Enomoto, Y. Ehara:
Highly sensitive determination of transient generation of biophotons during hypersensitive response to cucumber mosaic virus in cowpea.
J. Exp. Botany Vol. 58, No.3, pp.465-472 (2007) [pdf 2.07MB]M. Kobayashi, T. Mizumoto, Y. Shibuya, M. Enomoto, M. Takeda:
Fluorescence tomography in turbid media based on acousto-optic modulation imaging.
Appl. Phys. Lett. Vol. 89, No. 18, 181102 (2006)M Kobayashi, T Kasamatsu, Y Shibuya, M Enomoto:
Optical visualization of ultrasound pressure fields in turbid media based on a coherent detection imaging technique.
Jpn. J. Appl. Phys. Vol.45, No.A3, pp.1836-1840 (2006)
R. Van Wijk, M. Kobayashi, E. Van Wijk:
Anatomic characterization of human ultra-weak photon emission with a moveable photomultiplier and CCD imaging.
J. Photochem. Photobiol. B:Biology Vol.83, pp.69-76 (2006)
M. Nakajima, M. Takeda, Kobayashi, S. Suzuki, N. Ohuchi:
Nano-sized fluorescent particles as new tracers for sentinel node detection: experimental model for decision of appropriate size and wavelength.
Cancer Sci. Vol. 95, No.6, pp 353-356 (2005)
M. Takeda, M. Kobayashi, M. Takayama, S. Suzuki, T. Ishida, K. Ohnuki, T. Moriya, N. Ohuchi:
Biophoton detection as a novel technique for cancer imaging.
Cancer Sci, Vol. 95, No. 8, pp 656-661 (2004)
M. Kobayashi:
Spontaneous ultrweak photon emission of living organisms -biophotons- phenomena and detection techniques for extracting biological information,
Trends in Photochem. Photobiol., Vol.10, pp.111-135 (2003)
S. Yamaguchi, H. Isejima, T. Matsuo, R. Okura, K. Yagita, M. Kobayashi, H. Okamura:
Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus.
Science, Vol.302, No. 5649, pp 1408-1412 (2003)
M. Kobayashi:
Modern technology on physical analysis of biophoton emission and its potential extracting the physiological information.
Energy and Information Transfer in Biological System (F.Musumeci, L.S.Brizhik and M.W.Ho eds.) pp157-187, World Sci. Pub., Singapore (2003)
H.Terazono, T.Mutoh, S.Yamaguchi, M. Kobayashi, M.Akiyama, R.Udo, S.Ohdo, H.Okamura, S.Shibata:
Adrenergic regulation of clock gene expression in mouse liver
PNAS, Vol. 100, No. 11. pp. 6795-6800 (2003)
M. Kobayashi, M. Usa, H.inaba:
Highly sensitive detection and spectral analysis of ultraweak photon emission from living samples of human origin for the determination of biomedical information
Trans.SICE, Vol. E-1, No. 1. pp. 214-220 (2001)
M.Asai, S. Yamaguchi, H. Isejima, M. Jonouchi, T.Moriya, S. Shibata, M. Kobayashi, H. Okamura:
Visualization of mPer1 transcription in vitro: NMDA induces a rapid phase shift of mPer1 gene in cultured SCN
Current Biol., Vol. 11, pp. 1524-1527 (2001)S. Yamaguchi, M. Kobayashi, S. Mitsui, Y. Ishida, G. T. Horst, M. Suzuki, S. Shibata, H. Okamura:
View of a mouse clock gene ticking.
Nature, Vol. 409, No. 6821, p. 684 (2001)M. Kobayashi, H. Inaba:
Photon statistics and correlation analysis of ultraweak light originating from living organisms for extraction of biological information.
Appl Opt., Vol. 39, No. 1, pp. 183-192 (2000)S. Yamaguchi, S. Mitsui, S. Miyake, L. Yan, H. Onishi, K. Yagita, M. Suzuki, S. Shibata, M. Kobayashi, H. Okamura:
The 5'upstream region of mPer1 gene contains two promoters and is responsible for circadian oscillation.
Current Biol., Vol. 10, No. 14, pp.873-876 (2000)M. Kobayashi, M. Takeda, K.-I. Ito, H. Kato, H. Inaba:
Two-dimensional photon counting imaging and spatiotemporal characterization of ultraweak photon emission from a rat's brain in vivo.
J. Neurosci. Method, Vol. 93, No. 2, pp. 163-168 (1999)小林正樹:
細胞の自己組織化過程を光子で捉える
光学, Vol. 28, No. 10, pp. 561-566 (1999)M. Kobayashi, M. Takeda, T. Sato, Y. Yamazaki, K. Kaneko, K.-I. Ito, H. Kato, H. Inaba:
In vivo imaging of spontaneous ultraweak photon emission from a rat's brain correlated with cerebral energy metabolism and oxidative stress.
Neurosci. Res., Vol.34, No. 2, pp. 103-113 (1999)小林正樹，稲場文男:
バイオフォトンによる生体計測
医科器械学, Vol. 68, No. 8, pp. 347-356 (1998)M. Kobayashi, B. Devaraj, H. Inaba:
Observation of super-Poisson statistics from bacterial (Photobacterium phosphoreum) bioluminescence.
Phys. Rev. E., Vol. 64, No. 2, pp. 2129-2133(1998)福地圭介，B. Devaraj, 宇佐史，小林正樹，陳建培，稲場文男:
光ヘテロダイン検出法を用いた模擬生体試料（イントラリピッド10%）の可視部から近赤外域における分光透過特性の測定
光学, Vol. 27, No. 1, pp. 40-47 (1998)M. Takeda, Y. Tanno, M. Kobayashi, M. Usa, N. Ohuchi, S. Satomi, H. Inaba:
A Novel method of assessing carcinoma cell proliferation by biophoton emission.
Cancer Lett., Vol. 127, No. 1-2, 155-160 (1998)榎本幹，B. Devaraj，小林正樹，宇佐史，武田元博，石幡浩志，堀内博，稲場文男:
ヒトの歯のコヒーレント検出イメージング法によるレーザー光CT画像計測の研究
日本レーザー医学会誌, Vol. 19, No. 1, pp. 1-12 (1998)小林正樹，稲場文男:
極微弱生物フォトン発光現象の量子統計解析，時空間特性分析と生体情報計測への応用
レーザー研究，Vol. 25, No. 3, pp. 197-203 (1997)M. Kobayashi, B. Devaraj, M. Usa, Y. Tanno, M. Takeda and H. Inaba:
Two-dimensional Imaging of Ultraweak Photon Emission from Germinating Soybean Seedlings with a Highly Sensitive CCD Camera.
Photochem. Photobiol., Vol. 65, No. 3, pp. 535-537 (1997)榎本幹，鈴木健之，B. Devaraj，小林正樹, 宇佐史，武田元博，渡辺裕輝，湯浅哲也，赤塚孝雄，石幡浩志，遠藤英明，堀内博，稲場文男：
レーザーを用いたコヒーレント検出画像計測法による歯のコンピュータ断層（CT）画像の分光的測定
分光研究, Vol.46, No.3, pp.104-111 (1997)B.Devaraj, M.Takeda, M.Kobayashi, M.Usa, K.P.Chan, Y.Watanabe, T.Yuasa, T.Akatsuka, M.Ynmada, H.Inaba:
In vivo Laser Computed Tomographic Imaging of human Fingers by Coherent Detection Imaging Method using Different Wavelength in Near Infrared Region.
Applied Physics Letters, Vol. 69, No. 24, pp. 3671-3673 (1996)M. Kobayashi, B. Devaraj, M. Usa, Y. Tanno, M. Takeda and H. Inaba:
Development and Applications of New Technology for Two-dimensional Space-Time Characterization and Correlation analysis of Ultraweak Biophoton Information.
Frontiers Med. Biol. Engng., Vol. 7, No. 4, pp. 299-309 (1996)B.Devaraj, K.Fukuchi, Y.Watanabe, H.Ishihata, M.Kobayashi, T.Yuasa, H.Endo, M.Takeda, M.Usa, H.Horiuchi, T.Akatsuka, H.Inaba:
Laser Computed Tomographic Images of Bones and Teeth by Coherent Detection Imaging in the Visible and Near-IR Regions.In: OSA Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration Vol.2 (R.R.Alfano, J.G.Fujimoto eds.), pp. 214-219, Optical Society of America, Washington DC. (1996)T.Amano, M.Kobayashi, B.Devaraj, M.Usa, H.Inaba:
Ultraweak Biophoton Emission Imaging of Transplanted Bladder Cancer.
Urological Research, Vol. 23, pp. 315-318 (1995)B.Devaraj, M.Kobayashi, M.Usa, M.Takeda, H.Inaba, H.Ishihata, H.Horiuchi:
First Demonstration of Laser Computed Tomography of Human Tooth by Coherent Detection Imaging.
Electron. Lett., Vol. 31, No. 11, pp. 874-876 (1995)小林正樹，宇佐史，稲場文男：
生体情報計測のためのヒト由来生体試料の高感度極微弱発光検出およびスペクトル分析
計測自動制御学会論文集, Vol. 30, No. 4, pp. 385-391 (1994)M.Godlewski, Z. Rajfur, J.Slawinski, M.Kobayashi, M.Usa, H.Inaba:
Spectra of the Formaldehyde-induced Ultraweak Luminescence from Yeast Cells.
J. Photochem. Photobiol. B: Biol., Vol.21, pp.29-35 (1993)