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K Tsuchida, M. Kobayashi:
Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin.
Scientific Reports Vol. 10, 21667 (2020) [pdf]

K Tsuchida, M. Kobayashi:
Oxidative stress in human facial skin observed by ultraweak photon emission imaging and its correlation with biophysical properties of skin.
Scientific Reports Vol. 10, 9626 (2020) [pdf]

K Tsuchida, T. Iwasa, M. Kobayashi:
Imaging of ultraweak photon emission for evaluating the oxidative stress of human skin.
J Photochem Photomiol. B Vol. 198, 111562 (2019) [pdf]

S. Usui, M. Tada, M. Kobayashi:
Non-invasive visualization of physiological changes of insects during metamorphosis based on biophoton emission imaging.
Scientific Reports Vol. 9, Article number: 8576 (2019) [pdf]

M. Kobayashi, T. Iwasa, M. Tada:
Polychromatic spectral pattern analysis of ultra-weak photon emissions from a human body.

J. Photochem. Photobol. B: Biology Vol. 159, 186-190 (2016)

Y. Yamaguchi, K. Okada, T. Mizuno, T. Ota, H. Yamada, M. Doi, M. Kobayashi, H. Tei, Y. Shigeyoshi, H. Okamura:
Real-time recording of circadian Per1 and Per2 expression in the suprachiasmatic nucleus of freely moving rats.

J Biol Rhythms Vol. 31, No. 1, 108-111 (2016)

M. Kobayashi, N. Kikuchi, A. Sato:
Ultrasound-enhanced chemiluminescence tomography in biological tissue.

Ultrasonics Sonochemistry Vol. 31, 1-6 (2016)

M. He, E. Van Wijk, R. Berger, M. Wang, K. Strassburg, J. C. Schoeman, R. Vreeken, H. A. Van Wietmarschen, A. Harms, M. Kobayashi, T. Hankemeier. J. V. van der Greef:
Collagen induced arthritis in DBA/1J mice Associates with oxylipin changes in plasma.

Mediators of InflammationVol. 2015, Article ID 543541, 1-11 (2015)

M. Kobayashi, N. Kikuchi, A. Sato:
Optical tomography of fluorophores in dense scattering media based on ultrasound-enhanced chemiluminescence.

Appl. Phys. Lett. Vol. 106 021103 (2015)

M. Kobayashi:
Highly sensitive imaging for ultra-weak photon emission from living organisms.

J. Photochem. Photobiol. B: Biology Vol. 139, pp. 34-38 (2014)

E. van Wijk, M. Kobayashi, R. van Wijk, J. van der Greef:
Imaging of ultra-weak photon emission in a rheumatoid arthritis mouse model
PLoS ONE Vol. 8, No. 12, e84579 pp. 1-6 (2013)

Q. D. Trinh, S. Kaneta, M. Kobayashi:
Study on mechanism of ultrasonic fluorescence modulation in light scattering medium based on diffusion approximation with varying refractive index

Optical Review Vol. 19, No. 3, pp. 159-166 (2012)

Q. D. Trinh, S. Kaneta, M. Kobayashi:
Development of UltrasonicModulation Probe for Fluorescence Tomography Based on Acousto-Optic Effect

Int. J. Optics Vol. 2011, Artile ID 818302 (2011)
[pdf 1.31MB]

M. Doi,, A. Ishida, A. Miyake, M. Sato, R. Komatsu, F. Yamazaki, I. Kimura, S. Tsuchiya, H. Kori, K. Seo, Y. Yamaguchi, M. Matsuo, J-M. Fustin, R. Tanaka, Y. Santo, H. Yamada, Y. Takahashi, M. Araki, K. Nakao, S. Aizawa, M. Kobayashi, K. Obrietan, G. Tsujimoto, H. Okamura:
Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus

Nature communications, Vol. 2, article number 327 (2011)

M. Kobayashi, D. Kikuchi, H. Okamura:
Imaging of Ultraweak Spontaneous Photon Emission from Human Body Displaying Diurnal Rhythm

PLoS ONE Vol. 4, No. 7, e6256 (2009)
[pdf 0.24MB]

M. Kobayashi, T. Mizumoto, T. Q. Duc, M. Takeda:
Fluorescence Tomography of Biological Tissue Based on Ultrasound Tagging Technique
Proc. SPIE 6633, pp. 663306-1-5 (2007)

M. Kobayashi, K. Sasaki, M. Enomoto, Y. Ehara:
Highly sensitive determination of transient generation of biophotons during hypersensitive response to cucumber mosaic virus in cowpea.
J. Exp. Botany Vol. 58, No.3, pp.465-472 (2007) [pdf 2.07MB]

M. Kobayashi, T. Mizumoto, Y. Shibuya, M. Enomoto, M. Takeda:
Fluorescence tomography in turbid media based on acousto-optic modulation imaging.
Appl. Phys. Lett. Vol. 89, No. 18, 181102 (2006)

M Kobayashi, T Kasamatsu, Y Shibuya, M Enomoto:
Optical visualization of ultrasound pressure fields in turbid media based on a coherent detection imaging technique.
Jpn. J. Appl. Phys. Vol.45, No.A3, pp.1836-1840 (2006)

R. Van Wijk, M. Kobayashi, E. Van Wijk:
Anatomic characterization of human ultra-weak photon emission with a moveable photomultiplier and CCD imaging.
J. Photochem. Photobiol. B:Biology Vol.83, pp.69-76 (2006)

M. Nakajima, M. Takeda, Kobayashi, S. Suzuki, N. Ohuchi:
Nano-sized fluorescent particles as new tracers for sentinel node detection: experimental model for decision of appropriate size and wavelength.
Cancer Sci. Vol. 95, No.6, pp 353-356 (2005)

M. Takeda, M. Kobayashi, M. Takayama, S. Suzuki, T. Ishida, K. Ohnuki, T. Moriya, N. Ohuchi:
Biophoton detection as a novel technique for cancer imaging.
Cancer Sci, Vol. 95, No. 8, pp 656-661 (2004)

M. Kobayashi:
Spontaneous ultrweak photon emission of living organisms -biophotons- phenomena and detection techniques for extracting biological information,
Trends in Photochem. Photobiol., Vol.10, pp.111-135 (2003)

S. Yamaguchi, H. Isejima, T. Matsuo, R. Okura, K. Yagita, M. Kobayashi, H. Okamura:
Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus.
Science, Vol.302, No. 5649, pp 1408-1412 (2003)

M. Kobayashi:
Modern technology on physical analysis of biophoton emission and its potential extracting the physiological information.
Energy and Information Transfer in Biological System (F.Musumeci, L.S.Brizhik and M.W.Ho eds.) pp157-187, World Sci. Pub., Singapore (2003)

H.Terazono, T.Mutoh, S.Yamaguchi, M. Kobayashi, M.Akiyama, R.Udo, S.Ohdo, H.Okamura, S.Shibata:
Adrenergic regulation of clock gene expression in mouse liver
PNAS, Vol. 100, No. 11. pp. 6795-6800 (2003)

M. Kobayashi, M. Usa, H.inaba:
Highly sensitive detection and spectral analysis of ultraweak photon emission from living samples of human origin for the determination of biomedical information
Trans.SICE, Vol. E-1, No. 1. pp. 214-220 (2001)

M.Asai, S. Yamaguchi, H. Isejima, M. Jonouchi, T.Moriya, S. Shibata, M. Kobayashi, H. Okamura:
Visualization of mPer1 transcription in vitro: NMDA induces a rapid phase shift of mPer1 gene in cultured SCN
Current Biol., Vol. 11, pp. 1524-1527 (2001)

S. Yamaguchi, M. Kobayashi, S. Mitsui, Y. Ishida, G. T. Horst, M. Suzuki, S. Shibata, H. Okamura:
View of a mouse clock gene ticking.
Nature, Vol. 409, No. 6821, p. 684 (2001)

M. Kobayashi, H. Inaba:
Photon statistics and correlation analysis of ultraweak light originating from living organisms for extraction of biological information.
Appl Opt., Vol. 39, No. 1, pp. 183-192 (2000)

S. Yamaguchi, S. Mitsui, S. Miyake, L. Yan, H. Onishi, K. Yagita, M. Suzuki, S. Shibata, M. Kobayashi, H. Okamura:
The 5'upstream region of mPer1 gene contains two promoters and is responsible for circadian oscillation.
Current Biol., Vol. 10, No. 14, pp.873-876 (2000)

M. Kobayashi, M. Takeda, K.-I. Ito, H. Kato, H. Inaba:
Two-dimensional photon counting imaging and spatiotemporal characterization of ultraweak photon emission from a rat's brain in vivo.
J. Neurosci. Method, Vol. 93, No. 2, pp. 163-168 (1999)

光学, Vol. 28, No. 10, pp. 561-566 (1999)

M. Kobayashi, M. Takeda, T. Sato, Y. Yamazaki, K. Kaneko, K.-I. Ito, H. Kato, H. Inaba:
In vivo imaging of spontaneous ultraweak photon emission from a rat's brain correlated with cerebral energy metabolism and oxidative stress.
Neurosci. Res., Vol.34, No. 2, pp. 103-113 (1999)

医科器械学, Vol. 68, No. 8, pp. 347-356 (1998)

M. Kobayashi, B. Devaraj, H. Inaba:
Observation of super-Poisson statistics from bacterial (Photobacterium phosphoreum) bioluminescence.
Phys. Rev. E., Vol. 64, No. 2, pp. 2129-2133(1998)

福地圭介,B. Devaraj, 宇佐史,小林正樹,陳建培,稲場文男:
光学, Vol. 27, No. 1, pp. 40-47 (1998)

M. Takeda, Y. Tanno, M. Kobayashi, M. Usa, N. Ohuchi, S. Satomi, H. Inaba:
A Novel method of assessing carcinoma cell proliferation by biophoton emission.
Cancer Lett., Vol. 127, No. 1-2, 155-160 (1998)

榎本幹,B. Devaraj,小林正樹,宇佐史,武田元博,石幡浩志,堀内博,稲場文男:
日本レーザー医学会誌, Vol. 19, No. 1, pp. 1-12 (1998)

レーザー研究,Vol. 25, No. 3, pp. 197-203 (1997)

M. Kobayashi, B. Devaraj, M. Usa, Y. Tanno, M. Takeda and H. Inaba:
Two-dimensional Imaging of Ultraweak Photon Emission from Germinating Soybean Seedlings with a Highly Sensitive CCD Camera.
Photochem. Photobiol., Vol. 65, No. 3, pp. 535-537 (1997)

榎本幹,鈴木健之,B. Devaraj,小林正樹, 宇佐史,武田元博,渡辺裕輝,湯浅哲也,赤塚孝雄,石幡浩志,遠藤英明,堀内博,稲場文男:
分光研究, Vol.46, No.3, pp.104-111 (1997)

B.Devaraj, M.Takeda, M.Kobayashi, M.Usa, K.P.Chan, Y.Watanabe, T.Yuasa, T.Akatsuka, M.Ynmada, H.Inaba:
In vivo Laser Computed Tomographic Imaging of human Fingers by Coherent Detection Imaging Method using Different Wavelength in Near Infrared Region.
Applied Physics Letters, Vol. 69, No. 24, pp. 3671-3673 (1996)

M. Kobayashi, B. Devaraj, M. Usa, Y. Tanno, M. Takeda and H. Inaba:
Development and Applications of New Technology for Two-dimensional Space-Time Characterization and Correlation analysis of Ultraweak Biophoton Information.
Frontiers Med. Biol. Engng., Vol. 7, No. 4, pp. 299-309 (1996)

B.Devaraj, K.Fukuchi, Y.Watanabe, H.Ishihata, M.Kobayashi, T.Yuasa, H.Endo, M.Takeda, M.Usa, H.Horiuchi, T.Akatsuka, H.Inaba:
Laser Computed Tomographic Images of Bones and Teeth by Coherent Detection Imaging in the Visible and Near-IR Regions.In: OSA Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration Vol.2 (R.R.Alfano, J.G.Fujimoto eds.), pp. 214-219, Optical Society of America, Washington DC. (1996)

T.Amano, M.Kobayashi, B.Devaraj, M.Usa, H.Inaba:
Ultraweak Biophoton Emission Imaging of Transplanted Bladder Cancer.
Urological Research, Vol. 23, pp. 315-318 (1995)

B.Devaraj, M.Kobayashi, M.Usa, M.Takeda, H.Inaba, H.Ishihata, H.Horiuchi:
First Demonstration of Laser Computed Tomography of Human Tooth by Coherent Detection Imaging.
Electron. Lett., Vol. 31, No. 11, pp. 874-876 (1995)

計測自動制御学会論文集, Vol. 30, No. 4, pp. 385-391 (1994)

M.Godlewski, Z. Rajfur, J.Slawinski, M.Kobayashi, M.Usa, H.Inaba:
Spectra of the Formaldehyde-induced Ultraweak Luminescence from Yeast Cells.
J. Photochem. Photobiol. B: Biol., Vol.21, pp.29-35 (1993)